![]() ![]() Therefore, innovations in DRV formulations, based on its encapsulation in optically traceable nanoparticles (NPs), may improve its transport through the BBB, providing, at the same time, optical monitoring of drug delivery within the CNS. ![]() The antiretroviral drug darunavir (DRV) has been approved for therapy of HIV-infected patients, but its efficacy in the treatment of HIV-associated neurological disorders (HAND) is limited due to the low penetration through the blood–brain barrier (BBB). It's an interesting avenue for delivering drugs directly to the brain and improving the treatment for neurodegenerative diseases," said the researcher, who also holds the Louise and André Charron Research Chair on Alzheimer's Disease at the Armand-Frappier Foundation.Īccording to Société Alzheimer de Québec, neurodegenerative diseases currently affect more than 565,000 Canadians, including 152,121 in Québec.Human immunodeficiency virus (HIV) can independently replicate in the central nervous system (CNS) causing neurocognitive impairment even in subjects with suppressed plasma viral load. "Our findings demonstrate that the drug coating is a very important factor in the therapeutic use of nanoparticles. Professor Ramassamy pointed out that a mixture of both polymers could be considered to leverage the benefits of each. Thus, PEG remains the most attractive coating polymer with respect to the bloodstream, while the zwitterionic polymer would potentially result in a weaker immune system response. ![]() However, it is more rapidly absorbed by blood vessel walls, which reduces their circulation time," explained Professor Ramassamy. "With this type of experiment, we demonstrated that the zwitterionic polymer, which in theory is more biocompatible since it's similar to molecules at the cell's surface, have a better access to the brain. The second coating, made of zwitterionic polymer, was compared under the same conditions. The first coating, made of polyethylene glycol (PEG), had already been tested on the zebrafish, whose transparent body makes it possible to see the distribution of nanoparticles virtually in real time. ![]() The researchers compared the characteristics of two polymer coatings on the polylactic acid (PLA) nanoparticles, a biocompatible material easily cleared by the body. These molecules are neutral overall, and have an equal number of positive and negative charges to mimic the molecules on the cell's surface. In their recent study, the team demonstrated the effectiveness of a specific polymer with zwitterion properties. ![]()
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